United States securities and exchange commission logo

                          December 15, 2022

       Robert Ang, M.B.B.S.
       President and Chief Executive Officer
       Vor Biopharma Inc.
       100 Cambridgepark Drive, Suite 101
       Cambridge, MA 02140

                                                        Re: Vor Biopharma Inc.
Statement on Form S-3
                                                            Filed December 14,
                                                            File No. 333-268798

       Dear Robert Ang:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Jason
Drory at 202-551-8342 with any questions.


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Divakar Gupta